Mycofree 250mg Tablet

✔️ Uses of Mycofree 250mg Tablet

• Fungal Infections

✔️ How does Mycofree 250mg Tablet work?

Terbinafine works by stopping the production of a chemical known as ergosterol, which is responsible for forming the fungal cell membrane (the protective covering of the fungi). Thus, it kills the fungi and stops the spread of infections.

✔️ Side Effects of Mycofree 250mg Tablet

• Common side effects include gastrointestinal issues, abnormal liver tests, rashes, and taste disturbances.
• Severe adverse events are rare but may include liver damage, skin reactions, neutropenia, thrombocytopenia, angioedema, and allergic reactions.

✔️ Quick Suggestions:

• Terbinafine helps treat fungal infections of the skin and nails.
• Do not skip any doses and finish the full course of treatment even if you feel better.
• Treatment may be needed for 2 to 6 weeks for skin infections and 6 weeks to 6 months for nail infections.
• It can make your skin more sensitive to the sun. Use broad-spectrum sunscreen and protective clothing when outdoors.
• Your doctor may monitor your liver function regularly during treatment. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
• Inform your doctor if you are

✔️ Indications of Mycofree 250mg Tablet

Fungal nail infections, also known as onychomycosis, are frequently occurring infections affecting toenails or fingernails. These infections are caused by various types of fungi commonly found in the environment. The fungi gain entry into the nail through small openings or cracks in the nail or surrounding skin, leading to an infection. Symptoms of fungal nail infections often include thickened nails that may appear discolored (brown, yellow, or white), making them more prone to breakage. While these infections are generally not painful unless they become severe, they can be quite persistent. Fungal infections are more commonly observed in toenails than in fingernails.

Tinea capitis, commonly referred to as scalp ringworm, is another fungal infection that primarily affects the scalp, involving both the hair and the skin. This infection is contagious and manifests with symptoms such as dry, itchy, scaly patches on the scalp, hair loss, and redness. The term "ringworm" is used because of the circular or ring-shaped appearance of the affected areas. Tinea capitis predominantly occurs in children between the ages of 3 to 7 years.

✔️ Pharmacology

• Mycofree 250 contains Terbinafine, an Allylamine antifungal, which inhibits Squalene Epoxidase, suppressing the biosynthesis of Ergosterol, a crucial component of fungal cell membranes.
• It may be fungicidal based on drug concentration and in vitro testing against fungal species like Trichophyton Mentagrophyte and Trichophyton rubrum.

✔️ Dosage & Administration of Mycofree 250mg Tablet

Adult Dose:

Oral Onychomycosis:

• Fingernail: 250 mg once daily for 6 weeks
• Toenail: 250 mg once daily for 12 weeks

Tinea Pedis, Tinea Corporis, Tinea Cruris:

• 250 mg/day orally in a single dose or divided into two doses every 12 hours
• Treatment duration varies depending on the type of fungal infection: 2-4 weeks for tinea cruris and tinea corporis, and 2-6 weeks for tinea pedis

Hepatic Impairment: Terbinafine use is not recommended in individuals with chronic or active liver disease.

Child Dose:

Tinea Capitis:

• Children >4 years and weighing less than 25 kg: 125 mg/day orally for 6 weeks
• Children >4 years and weighing 25-35 kg: 187.5 mg/day orally for 6 weeks
• Children >4 years and weighing more than 35 kg: 250 mg/day orally for 6 weeks

Renal Dose:

Renal Impairment: Terbinafine use is not recommended if the creatinine clearance (CrCl) is less than 50 mL/min.

✔️ Interaction

Terbinafine inhibits the CYP450 2D6 isozyme, potentially affecting drugs metabolized by this enzyme.

✔️ Contraindications

Individuals with hypersensitivity to terbinafine should avoid products containing it.

✔️ Pregnancy & Lactation

Terbinafine is not recommended during pregnancy, and nursing mothers should avoid it as it's excreted in breast milk.

✔️ Precautions & Warnings

• Patients with chronic or active liver disease should not take terbinafine.
• Liver function tests are advised before starting terbinafine.
• Rare cases of liver failure and severe skin reactions have been reported.

✔️ Storage Conditions

Store in a cool and dry place below 30°C, protected from light.